Área de Concentração: 17137
Concentration area: 17137
Criação: 01/02/2022
Creation: 01/02/2022
Ativação: 01/02/2022
Activation: 01/02/2022
Nr. de Créditos: 3
Credits: 3
Carga Horária:
Workload:
Teórica (por semana) |
Theory (weekly) |
Prática (por semana) |
Practice (weekly) |
Estudos (por semana) |
Study (weekly) |
Duração | Duration | Total | Total |
---|---|---|---|---|---|---|---|---|---|
1 | 11 | 3 | 3 semanas | 3 weeks | 45 horas | 45 hours |
Docentes Responsáveis:
Professors:
Hélio Rubens Machado
Luiza da Silva Lopes
Marcelo Volpon Santos
Objetivos:
Caracterização clínica, anátomo-patológica e por imagens das malformações do SNC - Abordagem terapêutica das malformações. Implicações da abordagem multidisciplinar e o papel de cada membro da equipe. Resultados do tratamento a curto prazo e implicação das complicações como fatores de risco - Propor formas de acompanhamento a longo prazo e o envolvimento familiar como fator de minimização de riscos ao desenvolvimento cognitivo. Discutir inovações tecnológicas e aprofundar os conhecimentos no campo de estudo da hidrocefalia.
Justificativa:
As malformações do sistema nervoso são freqüentes e compatíveis com uma sobrevida em boas condições desde que atendam a determinados fatores e um destes talvez o mais importante, seja o a multidisciplinaridade. As lesões têm aspectos clínicos multivariados envolvendo muitos especialistas, tanto da área médica (neurologistas e neurocirurgiões, pediatras, geneticistas, neurofisiologistas, ortopedistas e urologistas), como de outras áreas (psicologia, fisioterapia, terapia ocupacional, etc.). O estudo constante, atualizado e multidisciplinar é a única forma coerente de abordagem destas lesões.
Conteúdo:
1. Aulas teóricas por especialistas de diversas áreas ligadas ao problema. 2. Aulas com enfoque nos estudos experimentais em modelos de hidrocefalia, além da abordagem da fisiopatologia e tratamento das lesões utilizando métodos da imagem (TC, US e RM) e vídeos cirúrgicos. 3. Discussão de inovações tecnológicas (neuroendoscopia) e monitorização intracraniana.
Forma de Avaliação:
1) Relatório de atividades e sobre um tema escolhido. 2) Participação em seminários, atividades práticas e outras. 3) Freqüência.
Bibliografia:
1) Ballestero MFM, Frigieri G, Cabella BCT, de Oliveira SM, de Oliveira RS. Prediction of intracranial hypertension through noninvasive intracranial pressure waveform analysis in pediatric hydrocephalus. Childs Nerv Syst. 2017;33(9):1517-1524. 2) Garcia CAB, Catalão CHR, Machado HR, Júnior IM, Romeiro TH, Peixoto-Santos JE, Santos MV, da Silva Lopes L. Edaravone reduces astrogliosis and apoptosis in young rats with kaolin-induced hydrocephalus. Childs Nerv Syst. 2017;33(3):419-428. 3) Catalão CHR, Shimizu GY, Tida JA, Garcia CAB, Dos Santos AC, Salmon CEG, Rocha MJA, da Silva Lopes L.Environmental enrichment reduces brain damage in hydrocephalic immature rats. Childs Nerv Syst. 2017;33(6):921-931. 4) Garegnani L, Franco JVA, Ciapponi A, Garrote V, Vietto V, Medina SAP: Ventriculo-peritoneal shunting devices for hydrocephalus. Cochrane Database Syst Rev. 2020;6(6):CD012726. 5) Kestle JRW & Riva-Cambrin J: Prospective multicenter studies in pediatric hydrocephalus. J Neurosurg Pediatr 2019;23(2):135-141. 6) Dorner RA, Burton VJ, Allen MC, Robinson S, Soares BP: Preterm neuroimaging and neurodevelopmental outcome: a focus on intraventricular hemorrhage, post-hemorrhagic hydrocephalus, and associated brain injury. J Perinatol. 2018; 38(11): 1431–1443. 7) Klebe D, McBride D, Krafft PR, Flores JJ, Tang J, Zhang JH: Post-Hemorrhagic Hydrocephalus Development after Germinal Matrix Hemorrhage: Established Mechanisms and Proposed Pathways. J Neurosci Res. 2020; 98(1): 105–120. 8) Karimy JK, Reeves BC, Damisah E, Duy PQ, Antwi P, David W, Wang K, Schiff Jr SJ, Limbrick DD, Alper SL, Warf BC, Nedergaard M, Simard JM, Kahle KT: Pathogenic mechanisms and therapeutic targets of inflammation in acquired hydrocephalus. Nat Rev Neurol. 2020; 16(5): 285–296. 9) Patel SK, Zamorano-Fernandez J, Nagaraj U, Bierbrauer KS, Mangano FT. Not all ventriculomegaly is created equal: diagnostic overview of fetal, neonatal and pediatric ventriculomegaly. Childs Nerv Syst. 2020;36(8):1681-1696. 10) Krishnan P, Raybaud C, Palasamudram S, Shroff M. Neuroimaging in Pediatric Hydrocephalus. Indian J Pediatr. 2019;86(10):952-960. 11) Deopujari CE, Padayachy L, Azmi A, Figaji A, Samantray SK. Neuroendoscopy for post-infective hydrocephalus in children. Childs Nerv Syst. 2018 ;34(10):1905-1914. 12) Sobana M, Halim D, Aviani JK, Gamayani U, Achmad TH. Neurodevelopmental outcomes after ventriculoperitoneal shunt placement in children with non-infectious hydrocephalus: a meta-analysis. Childs Nerv Syst. 2021 ;37(4):1055-1065. 13) Ferris CF, Cai X, Qiao J, Switzer B, Baun J, Morrison T, Iriah S, Madularu D, Sinkevicius KW, Kulkarni P. Life without a brain: Neuroradiological and behavioral evidence of neuroplasticity necessary to sustain brain function in the face of severe hydrocephalus. Sci Rep. 2019;9(1):16479. 14) Catalão CHR, Souza AO, Santos-Júnior NN, da Silva SC, da Costa LHA, Alberici LC, Rocha MJA, da Silva Lopes L. Kaolin-induced hydrocephalus causes acetylcholinesterase activity dysfunction following hypothalamic damage in infant rats. Brain Res. 2019;1724:146408. 15) Rekate HL. Hydrocephalus in infants: the unique biomechanics and why they matter. Childs Nerv Syst. 2020;36(8):1713-1728. 16) Dewan MC, Rattani A, Mekary R, Glancz LJ, Yunusa I, Baticulon RE, Fieggen G, Wellons JC, Park KB, Warf BC. Global hydrocephalus epidemiology and incidence: systematic review and meta-analysis. J Neurosurg. 2018:1-15. 17) Szefczyk-Polowczyk L, Mandera M. Functioning of the children with hydrocephalus. Acta Neurol Belg. 2020;120(2):345-353. 18) Wall VL, Kestle JRW, Fulton JB, Gale SD. Social-emotional functioning in pediatric hydrocephalus: comparison of the Hydrocephalus Outcome Questionnaire to the Behavior Assessment System for Children. J Neurosurg Pediatr. 2021:1-7. 19) Varela MF, Miyabe MM, Oria M. Fetal brain damage in congenital hydrocephalus. Childs Nerv Syst. 2020;36(8):1661-1668. 20) Peiro JL, Fabbro MD. Fetal therapy for congenital hydrocephalus-where we came from and where we are going. Childs Nerv Syst. 2020;36(8):1697-1712. 21) Sampaio GB, Da Silva SC, Romeiro TH, Beggiora PDS, Machado HR, Lopes LDS. Evaluation of the effects of quercetin on brain lesions secondary to experimental hydrocephalus in rats. Childs Nerv Syst. 2019;35(12):2299-2306. 22) El Damaty A, Marx S, Cohrs G, Vollmer M, Eltanahy A, El Refaee E, Baldauf J, Fleck S, Baechli H, Zohdi A, Synowitz M, Unterberg A, Schroeder HWS. ETV in infancy and childhood below 2 years of age for treatment of hydrocephalus. Childs Nerv Syst. 2020;36(11):2725-2731. 23) Weil AG, Westwick H, Wang S, Alotaibi NM, Elkaim L, Ibrahim GM, Wang AC, Ariani RT, Crevier L, Myers B, Fallah A. Efficacy and safety of endoscopic third ventriculostomy and choroid plexus cauterization for infantile hydrocephalus: a systematic review and meta-analysis. Childs Nerv Syst. 2016;32(11):2119-2131. 24) Li Y, Tan Z, Wang Y, Wang Y, Li D, Chen Q, Huang W. Detection of differentiated changes in gray matter in children with progressive hydrocephalus and chronic compensated hydrocephalus using voxel-based morphometry and machine learning. Anat Rec (Hoboken). 2020;303(8):2235-2247. 25) Gluski J, Zajciw P, Hariharan P, Morgan A, Morales DM, Jea A, Whitehead W, Marupudi N, Ham S, Sood S, McAllister JP 2nd, Limbrick DD Jr, Harris CA. Characterization of a multicenter pediatric-hydrocephalus shunt biobank. Fluids Barriers CNS. 2020;17(1):45. 26) Limbrick DD Jr, Baksh B, Morgan CD, Habiyaremye G, McAllister JP 2nd, Inder TE, Mercer D, Holtzman DM, Strahle J, Wallendorf MJ, Morales DM. Cerebrospinal fluid biomarkers of infantile congenital hydrocephalus. PLoS One. 2017;12(2):e0172353. 27) Henzi R, Vío K, Jara C, Johanson CE, McAllister JP, Rodríguez EM, Guerra M. Neural stem cell therapy of foetal onset hydrocephalus using the HTx rat as experimental model. Cell Tissue Res. 2020;381(1):141-161. 28) Isaacs AM, Riva-Cambrin J, Yavin D, Hockley A, Pringsheim TM, Jette N, Lethebe BC, Lowerison M, Dronyk J, Hamilton MG. Age-specific global epidemiology of hydrocephalus: Systematic review, metanalysis and global birth surveillance. PLoS One. 2018;13(10):e0204926. 29) Guzelcicek A, Koyuncu I, Gönel A, Cigdem G, Karadag M. Relationship Between Oxidative Stress, Tau Level and Antioxidant Mechanisms of the KEAP-1/NRF-2/HO-1 in Children with Hydrocephalus. Antiinflamm Antiallergy Agents Med Chem. 2020 Dec 27. doi: 10.2174/1871523019666201228111713. 30) Volpon Santos M, da Silva Lopes L, Machado HR, Santos de Oliveira R. Behavioral and Biochemical Features of the Course and Surgical Treatment of Experimental Obstructive Hydrocephalus in Young Rats. Dev Neurosci. 2019;41(1-2):34-43. 31) Tida JA, Catalão CHR, Garcia CAB, Dos Santos AC, Salmon CEG, Lopes LDS. Acupuncture at ST36 exerts neuroprotective effects via inhibition of reactive astrogliosis in infantile rats with hydrocephalus. Acupunct Med. 2018 ;36(6):386-393. 32) da Silva SC, Feres O, da Silva Beggiora P, Machado HR, Menezes-Reis R, Araújo JE, Brandão RA, da Silva Lopes L. Hyperbaric oxygen therapy reduces astrogliosis and helps to recovery brain damage in hydrocephalic young rats. Childs Nerv Syst. 2018;34(6):1125-1134. 33) de Moura Silva GAP, da Silva SC, da Silva Beggiora P, Matias Júnior I, Menezes-Reis R, Santos MV, Machado HR, da Silva Lopes L. Transcranial ultrasonography as a reliable instrument for the measurement of the cerebral ventricles in rats with experimental hydrocephalus: a pilot study. Childs Nerv Syst. 2021;37(6):1863-1869.
Idiomas ministrados:
Languages taught:
Tipo de oferecimento da disciplina:
Presencial
Class type:
Presencial