Disciplina Discipline RFI5802

Epilepsias: Complexidade e Comorbidades
Epilepsies: Complexity and Comorbidities

Área de Concentração: 17134

Concentration area: 17134

Criação: 17/08/2023

Creation: 17/08/2023

Ativação: 17/08/2023

Activation: 17/08/2023

Nr. de Créditos: 2

Credits: 2

Carga Horária:

Workload:

Teórica (por semana)	Theory (weekly)	Prática (por semana)	Practice (weekly)	Estudos (por semana)	Study (weekly)	Duração	Duration	Total	Total
24	0	6	1 semanas	1 weeks	30 horas	30 hours

Teórica

(por semana)

Theory

(weekly)

Prática

(por semana)

Practice

(weekly)

Estudos

(por semana)

Study

(weekly)

Duração

Duration

Total

1 semanas

1 weeks

30 horas

30 hours

Docente Responsável:

Professor:

Norberto Garcia Cairasco

Objetivos:

Desde 1998 o Laboratório de Neurofisiologia e Neuroetologia Experimental (LNNE) da Faculdade de Medicina de Ribeirão Preto (FMRP) da Universidade de São Paulo, tem celebrado cada 5 anos um Simpósio Acadêmico e Científico: Neurociências Integrativas (1998), Neuro-Arte (2003), Contemporary Neurosciences, Epilepsies and the Arts (NEWroscience 2008), Epilepsies: Complexity and Comorbidities (NEWroscience 2013) e Looking for Epilepsy Cure Along Centuries and Across Cultures – From Demons and Blessings to Brain Complex Networks and DNA Editing (NEWroscience 2018). O Simpósio NEWroscience (2008) foi acompanhado pela publicação de Suplemento, e os Simpósios NEWroscience (2013 e 2018) de volumes especiais (Special Issues) todos da Revista Epilepsy & Behavior (E&B). Esta importante publicação, a de maior importância internacional foi fundada e teve até 2021 como Editor-in-Chief o Professor Steve C. Schachter (Harvard University). Em todos esses volumes da E&B Norberto Garcia-Cairasco (FMRP-USP), atuou como Guest-Editor. Em cada volume cada palestrante convidado escreveu um excelente Review. Em 2023 celebraremos 35 anos da existência do LNNE junto com o International Symposium NEWroscience 2023: Epilepsy & Neuropsychiatric Comorbidities From Semiology, to Neuroplasticity of Vulnerable/Resilient Networks, to Personalized Therapies. De maneira semelhante ao que aconteceu nas três versões anteriores dos Simpósios NEWroscience, publicaremos outro Volume Especial da Revista E&B sem custo para cada autor de Review. Nesta edição trabalharemos com 30 palestrantes (15 mulheres e 15 homens) vindos de 5 diferentes continentes e de várias regiões do Brasil, de uma enorme variedade de especialidades em Neurociências, Epileptologia, Neuropsiquiatria, distribuídos em seis Mesas Redondas temáticas (5 palestrantes), onde cada Palestrante Convidado terá 30 minutos para a sua fala, seguidos de 60 minutos para Discussão Geral. Consideramos que este evento, de formato único, estruturado para "pensar fora da caixa" seja uma grande oportunidade para o encontro e troca de experiências em neurociências com líderes mundiais no campo da epilepsia e suas comorbidades, com as novas gerações de neurocientistas, num ambiente rico com desenvolvimentos plurais, integrativos, históricos e de alta tecnologia, para propor as tremendamente necessárias "mudanças de paradigma". O programa completo do NEWroscience 2023, assim como aconteceu no NEWroscience 2018, será oferecido (em Inglês) como Disciplina do Programa de Pós-Graduação de Fisiologia da FMRP-USP.

Objectives:

Since 1998, the Neurophysiology and Experimental Neuroethology Laboratory (LNNE) of the Ribeirão Preto School of Medicine (FMRP) of the University of São Paulo has celebrated every 5 years an Academic and Scientific Symposium: Integrative Neurosciences (1998), Neuro-Art (2003), Contemporary Neurosciences, Epilepsies and the Arts (NEWroscience 2008), Epilepsies: Complexity and Comorbidities (NEWroscience 2013) and Looking for Epilepsy Cure Along Centuries and Across Cultures - From Demons and Blessings to Brain Complex Networks and DNA Editing (NEWroscience 2018). The NEWroscience Symposium (2008) was accompanied by the publication of a Supplement and the NEWroscience Symposia (2013 and 2018) were accompanied by the publication of Special Issues of the Epilepsy & Behavior Journal (E&B). This publication is the most important in its field and was founded and has until 2021 as Editor-in-Chief Professor Steve C. Schachter (Harvard University). Norberto Garcia-Cairasco (FMRP-USP), has acted as Guest-Editor, with each invited speaker writing an excellent Review in those volumes. In 2023 we will celebrate 35 years of LNNE’s existence along with the International Symposium NEWroscience 2023: Epilepsy & Neuropsychiatric Comorbidities. From Semiology, to Neuroplasticity of Vulnerable/Resilient Networks, to Personalized Therapies. Similar to what happened in the three previous versions of the NEWroscience Symposia, we will publish another Special Issue of the E&B Journal at no cost to each Review author. In this edition, we will work with 30 speakers (15 women and 15 men) from 5 different continents and from various regions of Brazil, from a huge variety of specialties in Neuroscience, Epileptology and Neuropsychiatry, distributed in six thematic Round Tables (5 speakers each), where each Invited Speaker will have 30 minutes for their speech, followed by 60 minutes for General Discussion. We consider that this unique format event, structured to “think outside the box”, is a great opportunity for meeting and exchanging experiences in neuroscience with world leaders in the field of epilepsy and its comorbidities, with the new generations of neuroscientists, in a rich environment with pluralistic, integrative, historical, and high-tech developments, to propose the tremendously necessary “paradigm shifts”. The complete program of NEWroscience 2023, as happened in NEWroscience 2018, will be offered (in English) as a Discipline of the Graduate Program in Physiology of FMRP-USP.

Justificativa:

Estamos confiantes que o NEWroscience 2023, assim como edições anteriores, terá um forte impacto para o progresso da Investigação em Epilepsia e Comorbidades Neuropsiquiátricas ao promover a discussão sobre a forma como os cientistas têm olhado para o seu objeto de estudo ao longo dos séculos, através das culturas e ao longo dos desenvolvimentos científicos e tecnológicos. Sistemas Complexos demandam formas complexas de análise e embora quase impossíveis de serem estudados por esta ótica no passado, o crescente poder computacional e a grande quantidade de dados gerados ao longo das décadas, somados a mentes intrigantes e muito suor nos ajudarão a resolver o quebra-cabeça das Epilepsias e suas Comorbidades Neuropsiquiátricas. Estamos reunindo no NEWroscience 2023 um time único de Palestrantes de todos os continentes do mundo, para discutir desafios e perspectivas para pesquisa em epilepsia, epilepsia, comorbidades e comorbidades psiquiátricas, sistemas complexos, neurotecnologias, etc. Para enriquecer o evento incentivamos vivamente a participação de todos os Neurocientistas Clínicos e Básicos, Neurologistas Clínicos, Neuropsiquiatras, Psicólogos, Biólogos Moleculares, Fisioterapeutas, Físicos, Engenheiros Biomédicos, Artistas Plásticos e todos os interessados académica, artística ou socialmente neste encontro desafiante e integrador. As palestras serão publicadas como Revisão ou Artigos Originais em um Volume Especial da Epilepsy & Behavior com a Editoria de Norberto Garcia-Cairasco e Marcio F. Dutra Moraes e o Professor Marco Mula como seu atual Editor-Chefe. Além disso, incentivamos fortemente a participação de Estudantes de Graduação e Pós-Graduação, Pós-Docs e todos os pesquisadores interessados com a submissão de Resumos para serem apresentados como Pôsteres. Teremos três categorias de Resumos: Resumos de Epilepsia; Resumos de Neurociência e Resumos de Neuro-Artes. O evento foi elaborado com 6 Mesas Redondas Temáticas: (1) O que podemos aprender com a Combinação de Epistemologias Científicas Ortodoxas e Ancestrais, Múltiplos Saberes, aplicados à Epilepsia e às Comorbidades Neuropsiquiátricas? (2) Da Bancada ao Leito: Novas Técnicas de Análise do Comportamento e Atividade Cerebral Correlacionada. (3) Canais, neurônios, glia e protagonistas vasculares de redes epileptogênicas complexas. (4) Epilepsia e Comorbidades Neuropsiquiátricas. Desafios para o diagnóstico, tratamento e conceito de farmacorresistência. (5) Neuropatologia, Inflamação, Conectomas, Neuroplasticidade Negativa e Positiva. (6) Mudanças de paradigma para visões integrativas na pesquisa das epilepsias e comorbidades neuropsiquiátricas.

Rationale:

We are confident that NEWroscience 2023, like in previous editions, will have a strong impact for the progress of Epilepsy Research and Neuropsychiatric Comorbidities by promoting the discussion on how scientists have looked at their object of study over centuries, across cultures and along scientific and technological developments. Complex Systems demand complex ways of analysis and although almost impossible to be studied by this optic in the past, the growing computational power and the large amount of data generated over the decades, summed with intriguing minds and a lot of sweat will help us solving the puzzle of the Epilepsies and their Neuropsychiatric Comorbidities. We are gathering at the NEWroscience 2023 a quite unique team of Invited Speakers from all continents of the world, to discuss challenges and perspectives for epilepsy research, epilepsy, comorbities and psychiatric comorbidities, complex systems, neurotechnologies, etc. To enrich the event we strongly encourage the participation of all Clinical and Basic Neuroscientists, Clinical Neurologists, Neuropsychiatrists, Psychologists, Molecular Biologists, Physical Therapists, Physicists, Biomedical Engineers, Plastic Artists, and anybody interested academically, artistically or socially in this challenging and integrative meeting. The lectures will be published as Review or Original Articles in a Special Issue of Epilepsy & Behavior with the Guest-Editorship of Dr. Norberto Garcia-Cairasco and Marcio F. Dutra Moraes and Dr. Marco Mula as Editor in-Chief. Moreover, we strongly encourage the participation of Undergraduate and Graduate Students, Post-Docs and all interested researchers with submission of Abstracts to be presented as Posters. We will have three categories of Abstracts: Epilepsy Abstracts; Neuroscience Abstracts and Neuro-Arts Abstracts. The event was prepared with 6 Thematic Roundtables: (1) What can we learn from the Combination of Orthodox Scientific and Ancestral Epistemologies, Multiple Knowledges, as applied to Epilepsy and Neuropsychiatric Comorbidities? (2) From Bench to Bedside: New Techniques for Analyzing Behavior and Correlated Brain Activity. (3) Channels, Neurons, Glia and Vascular Protagonists of Complex Epileptogenic Networks. (4) Epilepsy and Neuropsychiatric Comorbidities. Challenges for Diagnosis, Treatment, and the Concept of Pharmacoresistance. (5) Neuropathology, Inflammation, Connectomes, Negative and Positive Neuroplasticity. (6) Paradigm Shifts towards Integrative Views in the Research of the Epilepsies and Neuropsychiatric Comorbidities.

Conteúdo:

19th September 7:00 PM - 7:15 PM OPENING CEREMONY 7:15 PM - 8:00 PM KEYNOTE SPEECH Norberto Garcia-Cairasco - Physiology Department. Ribeirão Preto Medical School. University of São Paulo. Promoting Paradigm Shifts in Epileptology over Four Decades. The Neurophysiology and Experimental Neuroethology Laboratory (LNNE) Historical Contributions in Brazil, Latin America, and the World <ngcairas@usp.br> 8:00PM - 10:00PM WELCOME COCKTAIL 20th September 8:15AM - 12:15AM First Round Table: Morning Session What can we learn from the Combination of Orthodox Scientific and Ancestral Epistemologies, Multiple Knowledges, as applied to Epilepsy and Neuropsychiatric Comorbidities? Chair: Norberto Garcia-Cairasco; Co-Chair: Sandra Orozco 8:15AM - 8:45AM 1. Dinesh Upadhya. - Department of Anatomy, Kasturba Medical College, Manipal, India. Joining Ayurvedic Medicine and Contemporary Neuroscience in Epileptology Research <dineshupadhya@gmail.com> 8:45AM - 9:15AM 2. Symon Kariuki. KEMRI/Wellcome Trust Research Program: Kilifi, Kenia, Africa. Integrating Traditional and Complementary Medicine in the Treatment of Epilepsies and Comorbidities. African Challenges and Reflections <skariuki@kemri-wellcome.org> 9:15AM - 09:45AM 3. Elizabeth Dogbey. School of Pharmacy, Department of Pharmacology and Toxicology, University of Ghana, Accra, Ghana, Africa. Integrating Traditional Healers Knowledge and Ethnopharmacology with Contemporary Neurology in the Epilepsies <knoxemaliz2002@yahoo.com> 09:45AM - 10:15AM COFFEE-BREAK 10:15AM - 10:45AM 4. Bruno Benitez. Harvard Medical School - Beth Israel Deaconess Medical Center Broad Institute - MIT & Harvard. Boston, USA. A Multi-Omic Approach Applied to Alzheimer's Disease and Epilepsy <bbenitez@bidmc.harvard.edu> 10:45AM - 11:15M 5. Sergio Nojiri. Ribeirão Preto Law School. University of São Paulo, Ribeirão Preto, Brasil. Neuroscience, Law and the Epilepsies <nojiri@usp.br> 11:15AM - 12:15AM GENERAL DISCUSSION 12:15AM - 2:00PM LUNCH-BREAK 20th September 2:00PM – 6:00PM Second Round Table - Afternoon Session From Bench to Bedside: New Techniques for Analyzing Behavior and Correlated Brain Activity Chair: Maria Elisa Calcagnotto; Co-Chair: Patrick Forcelli 2:00 PM - 2:30PM 1. Maria Emília Rodrigues de Oliveira Thais. Departamento de Neurologia. Universidade Federal de Santa Catarina. Florianópolis, Brasil. Theory of Mind in the Epilepsies <mariaemiliathais@me.com> 2:30 PM - 3:00PM 2. Claudia Maurer-Morelli. Universidade Estadual de Campinas, Campinas, Brasil. From Zebrafish to Epileptic seizures in Patients: The Power of Translation <cmorelli@unicamp.br> 3:00 PM - 3:30PM 3. Aline Pansani. Department of Physiological Sciences - Biological Sciences Institute, Universidade Federal de Goiás. Goiás, Brasil. From Breath to Beat: The Cardiorespiratory Factors in SUDEP <alineppansani@gmail.com> 3:30 PM - 4:00PM COFFEE-BREAK 4:00 PM - 4:30PM 4. Hana Kubová. Department of Developmental Epileptology, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic. The behavioural Outcome of Status Epilepticus. Lessons from Laboratory Animals <kubova@biomed.cas.cz> 4:30 PM - 5:00PM 5. Maria Elisa Calcagnotto. Universidade Federal do Rio Grande do Sul. Porto Alegre, Brasil. Synaptic and Brain Oscillation Patterns in Misshapen Neuronal Networks <elisa.calcagnotto@ufrgs.br> 5:00 PM - 6:00PM GENERAL DISCUSSION 21st September 8:15AM – 6:00PM Third Round Table - Morning Session Channels, Neurons, Glia and Vascular Protagonists of Complex Epileptogenic Networks Chair: Prof. Victor R. Santos; Co-Chair: Vera Cristina Terra 8:15AM - 8:45AM 1. Olagide Wagner de Castro. Universidade Federal de Alagoas. Maceió, Brasil. Crack Cocaine and Epilepsy: What We Do Not Know Yet? <olagidewww@gmail.com> 8:45AM - 9:15AM 2. Patrick Forcelli. Georgetown University, Washington DC, USA. Basal Ganglia-Brainstem Networks in Epilepsy <paf22@georgetown.edu> 9:15AM - 9:45AM 3. Jenny Hsieh. Univ Texas San Antonio, San Antonio, USA. Stem Cell Approaches to Understanding Acquired and Genetic Epilepsies <jenny.hsieh@utsa.edu> 9:45AM - 10:15AM COFFEE-BREAK 10:15AM - 10:45AM 4. Cristina Ruedell Reschke. RCI University of Medicine and Health Sciences, School of Pharmacy and Biomolecular Sciences, Dublin, Ireland. The Molecular Rhythms of Epileptogenesis <cristinarreschke@rcsi.com> 10:45AM - 11:15AM 5. Alberto Lazarowski. Faculty of Pharmacy and Biochemistry, University of Buenos Aires. Buenos Aires, Argentina. Ferroptosis in the Epileptic Context and Risk of SUDEP <alazarowski@gmail.com> 11:15AM - 12:15AM GENERAL DISCUSSION 12:15AM - 2:00PM LUNCH-BREAK 21st September 2:00PM - 6:00PM Fourth Round Table - Afternoon Session Epilepsy and Neuropsychiatric Comorbidities. Challenges for Diagnosis, Treatment, and the Concept of Pharmacoresistance Chair: Prof. Luisa Rocha; Co-Chair: Prof. Alan Talevi 2:00PM - 2:30PM 1. Vera Cristina Terra. Comprehensive Care Center for Epilepsy –EPICENTRO, Nossa Senhora das Graças Hospital, Curitiba, Brasil. Pseudoseizures, Seizures and Epilepsies: How Can we Objectively Differentiate them? <v.c.terra@gmail.com> 2:30PM - 3:00AM 2. Luisa Rocha - Universidad Autónoma de Mexico. Ciudad de Mexico, Mexico. Pharmacoresistance in the Epilepsies: Clues from Animal Models and Resected Human Tissue <lrocha@cinvestav.mx> 3:00PM - 3:30PM 3. Alan Talevi. Laboratorio de Investigación y Desarrollo de Bioactivos Universidad de La Plata. La Plata, Argentina. The Underestimated Association Between Drug Resistant Epilepsies and Neuropsychiatric Comorbidities <atalevi@biol.unlp.edu.ar> 3:30PM - 4:00PM COFFEE-BREAK 4:00PM - 4:30PM 4. Idrish Ali. - Monash University. Melbourne, Australia. Neuroinflammation as Biomarker and Preventive Option for Epilepsy and Neurobehavioural Consequences <idrish.ali@monash.edu 4:30PM - 5:00PM 5. Peter A. Tass. Department of Neurosurgery, Stanford University School of Medicine, Stanford, USA. Vibrotactile Fingertip Stimulation for the Treatment of Parkinson’s Disease and Possible Applications to Epilepsy <ptass@stanford.edu> 5:00PM - 6:00PM GENERAL DISCUSSSION 22nd September 8:15AM - 11:15AM Fifth Round Table - Morning Session Neuropathology, Inflammation, Connectomes, Negative and Positive Neuroplasticity Chair: Cristina Ruedell Reschke; Co-Chair: Olagide Wagner de Castro 8:15AM - 8:45AM 1. Rossella Di Sapia. Laboratory of Experimental Neurology - Mario Negri Institute for Pharmacological Research. Milano. Italy. Neuroactive Peptides and Inflammatory Mediators in the Etiopathogenesis of Seizures and their Impact in the Mechanisms of Pharmacoresistance <rossella.disapia@marionegri.it> 8:45AM - 9:15AM 2. Sandra Orozco. Medical Research Unit in Neurological Diseases, Specialty Hospital, National Medical Center, Ciudad de Mexico, Mexico. Assessment of Neuroinflammation in Drug - Resistant Epilepsy: The Role of Autoimmunity <sorozco5@hotmail.com> 9:15AM - 9:45AM 3. Victor Rodrigues Santos. Universidade Federal de Minas Gerais. Belo Horizonte, Brasil. The Treatment of Immature Brain Seizures and Epileptogenesis from the Viewpoint of Cannabinoids <victorrsantos@gmail.com> 9:45AM - 10:15AM COFFEE-BREAK 10:15AM - 10:45AM 4. Maira Licia Foresti - Universidade Federal de São Paulo. São Paulo, Brazil. Modeling of Post-Traumatic Epilepsy and Experimental Research aimed at its Prevention <mairalicia@yahoo.com.br> 10:45AM to 11:15AM 5. Efrain Buriticá. Universidad del Valle. Cali, Colombia. On Post-Traumatic Epilepsies and other Drug-Resistant Epilepsies: In the Search for Biomarkers in Surgical Human Brain Tissue <efrain.buritica@correounivalle.edu.co> 11:15AM - 12:15AM GENERAL DISCUSSION 12:15AM – 2:00PM LUNCH-BREAK 22nd September 2:00PM - 6:00PM Sixth Round Table - Afternoon Session Paradigm Shifts towards Integrative Views in the Research of the Epilepsies and Neuropsychiatric Comorbidities Chair: Prof. Marcio Flávio Dutra Moraes; Co-Chair: Hana Kubová 2:00PM - 2:30PM 1. Candi LaSarge. Department of Anesthesia. Cincinnati Children's Hospital. University of Cincinnati. Cincinnati, USA. mTOR Hyperactivity Initiates an Epileptogenic Cascade <candi.lasarge@cchmc.org> 2:30PM - 3:00PM 2. Ana Carolina Coan. Department of Neurology Universidade de Campinas - UNICAMP. Campinas. Brasil. Mapping the Maze: Navigating the Complex Relationship of Epilepsy, White Matter Integrity, and Neurodevelopmental Impairment. <acoan@unicamp.br> 3:00PM to 3:30PM 3. David-Ahmedt Aristizabal. Imaging and Computer Vision Group CSIRO Data61. Canberra, Australia. Computer Vision for Understanding Patients’ Behavior: A Focus on Epilepsy and other Motor Disorders <david.ahmedtaristizabal@data61.csiro.au> 3:30PM to 4:00PM COFFEE-BREAK 4:00PM - 4:30PM 4. Marcio F.D. Moraes. University of Minas Gerais. Belo Horizonte, Brasil. Changing a Localizationist Brain Architecture View for One of Temporally Organized Packages. The Concept of Coincidence Detectors instead of Integration-Response and its Impact in the Treatment of the Epilepsies <marcionnc@gmail.com> 4:30PM - 5:00PM 5. Norberto Garcia-Cairasco. Ribeirão Preto School of Medicine. University of São Paulo. Ribeirão Preto, Brasil. Challenges to Decipher the Main Intertwined Protagonists of Epileptogenesis and Comorbidities in a Complex Landscape of Semiology, Neuroanatomical Networks, and their Neuroplastic Abnormal Activity <ngcairas@usp.br> 5:00PM-6:00PM GENERAL DISCUSSION 6:00PM to 6:30PM GENERAL REFLEXIONS/FINAL COMMENTARIES 6:30PM to 7:00PM CLOSING REMARKS

Content:

CONTEÚDO EM INGLES: 19th September 7:00 PM - 7:15 PM OPENING CEREMONY 7:15 PM - 8:00 PM KEYNOTE SPEECH Norberto Garcia-Cairasco - Physiology Department. Ribeirão Preto Medical School. University of São Paulo. Promoting Paradigm Shifts in Epileptology over Four Decades. The Neurophysiology and Experimental Neuroethology Laboratory (LNNE) Historical Contributions in Brazil, Latin America, and the World <ngcairas@usp.br> 8:00PM - 10:00PM WELCOME COCKTAIL 20th September 8:15AM - 12:15AM First Round Table: Morning Session What can we learn from the Combination of Orthodox Scientific and Ancestral Epistemologies, Multiple Knowledges, as applied to Epilepsy and Neuropsychiatric Comorbidities? Chair: Norberto Garcia-Cairasco; Co-Chair: Sandra Orozco 8:15AM - 8:45AM 1. Dinesh Upadhya. - Department of Anatomy, Kasturba Medical College, Manipal, India. Joining Ayurvedic Medicine and Contemporary Neuroscience in Epileptology Research <dineshupadhya@gmail.com> 8:45AM - 9:15AM 2. Symon Kariuki. KEMRI/Wellcome Trust Research Program: Kilifi, Kenia, Africa. Integrating Traditional and Complementary Medicine in the Treatment of Epilepsies and Comorbidities. African Challenges and Reflections <skariuki@kemri-wellcome.org> 9:15AM - 09:45AM 3. Elizabeth Dogbey. School of Pharmacy, Department of Pharmacology and Toxicology, University of Ghana, Accra, Ghana, Africa. Integrating Traditional Healers Knowledge and Ethnopharmacology with Contemporary Neurology in the Epilepsies <knoxemaliz2002@yahoo.com> 09:45AM - 10:15AM COFFEE-BREAK 10:15AM - 10:45AM 4. Bruno Benitez. Harvard Medical School - Beth Israel Deaconess Medical Center Broad Institute - MIT & Harvard. Boston, USA. A Multi-Omic Approach Applied to Alzheimer's Disease and Epilepsy <bbenitez@bidmc.harvard.edu> 10:45AM - 11:15M 5. Sergio Nojiri. Ribeirão Preto Law School. University of São Paulo, Ribeirão Preto, Brasil. Neuroscience, Law and the Epilepsies <nojiri@usp.br> 11:15AM - 12:15AM GENERAL DISCUSSION 12:15AM - 2:00PM LUNCH-BREAK 20th September 2:00PM – 6:00PM Second Round Table - Afternoon Session From Bench to Bedside: New Techniques for Analyzing Behavior and Correlated Brain Activity Chair: Maria Elisa Calcagnotto; Co-Chair: Patrick Forcelli 2:00 PM - 2:30PM 1. Maria Emília Rodrigues de Oliveira Thais. Departamento de Neurologia. Universidade Federal de Santa Catarina. Florianópolis, Brasil. Theory of Mind in the Epilepsies <mariaemiliathais@me.com> 2:30 PM - 3:00PM 2. Claudia Maurer-Morelli. Universidade Estadual de Campinas, Campinas, Brasil. From Zebrafish to Epileptic seizures in Patients: The Power of Translation <cmorelli@unicamp.br> 3:00 PM - 3:30PM 3. Aline Pansani. Department of Physiological Sciences - Biological Sciences Institute, Universidade Federal de Goiás. Goiás, Brasil. From Breath to Beat: The Cardiorespiratory Factors in SUDEP <alineppansani@gmail.com> 3:30 PM - 4:00PM COFFEE-BREAK 4:00 PM - 4:30PM 4. Hana Kubová. Department of Developmental Epileptology, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic. The behavioural Outcome of Status Epilepticus. Lessons from Laboratory Animals <kubova@biomed.cas.cz> 4:30 PM - 5:00PM 5. Maria Elisa Calcagnotto. Universidade Federal do Rio Grande do Sul. Porto Alegre, Brasil. Synaptic and Brain Oscillation Patterns in Misshapen Neuronal Networks <elisa.calcagnotto@ufrgs.br> 5:00 PM - 6:00PM GENERAL DISCUSSION 21st September 8:15AM – 6:00PM Third Round Table - Morning Session Channels, Neurons, Glia and Vascular Protagonists of Complex Epileptogenic Networks Chair: Prof. Victor R. Santos; Co-Chair: Vera Cristina Terra 8:15AM - 8:45AM 1. Olagide Wagner de Castro. Universidade Federal de Alagoas. Maceió, Brasil. Crack Cocaine and Epilepsy: What We Do Not Know Yet? <olagidewww@gmail.com> 8:45AM - 9:15AM 2. Patrick Forcelli. Georgetown University, Washington DC, USA. Basal Ganglia-Brainstem Networks in Epilepsy <paf22@georgetown.edu> 9:15AM - 9:45AM 3. Jenny Hsieh. Univ Texas San Antonio, San Antonio, USA. Stem Cell Approaches to Understanding Acquired and Genetic Epilepsies <jenny.hsieh@utsa.edu> 9:45AM - 10:15AM COFFEE-BREAK 10:15AM - 10:45AM 4. Cristina Ruedell Reschke. RCI University of Medicine and Health Sciences, School of Pharmacy and Biomolecular Sciences, Dublin, Ireland. The Molecular Rhythms of Epileptogenesis <cristinarreschke@rcsi.com> 10:45AM - 11:15AM 5. Alberto Lazarowski. Faculty of Pharmacy and Biochemistry, University of Buenos Aires. Buenos Aires, Argentina. Ferroptosis in the Epileptic Context and Risk of SUDEP <alazarowski@gmail.com> 11:15AM - 12:15AM GENERAL DISCUSSION 12:15AM - 2:00PM LUNCH-BREAK 21st September 2:00PM - 6:00PM Fourth Round Table - Afternoon Session Epilepsy and Neuropsychiatric Comorbidities. Challenges for Diagnosis, Treatment, and the Concept of Pharmacoresistance Chair: Prof. Luisa Rocha; Co-Chair: Prof. Alan Talevi 2:00PM - 2:30PM 1. Vera Cristina Terra. Comprehensive Care Center for Epilepsy –EPICENTRO, Nossa Senhora das Graças Hospital, Curitiba, Brasil. Pseudoseizures, Seizures and Epilepsies: How Can we Objectively Differentiate them? <v.c.terra@gmail.com> 2:30PM - 3:00AM 2. Luisa Rocha - Universidad Autónoma de Mexico. Ciudad de Mexico, Mexico. Pharmacoresistance in the Epilepsies: Clues from Animal Models and Resected Human Tissue <lrocha@cinvestav.mx> 3:00PM - 3:30PM 3. Alan Talevi. Laboratorio de Investigación y Desarrollo de Bioactivos Universidad de La Plata. La Plata, Argentina. The Underestimated Association Between Drug Resistant Epilepsies and Neuropsychiatric Comorbidities <atalevi@biol.unlp.edu.ar> 3:30PM - 4:00PM COFFEE-BREAK 4:00PM - 4:30PM 4. Idrish Ali. - Monash University. Melbourne, Australia. Neuroinflammation as Biomarker and Preventive Option for Epilepsy and Neurobehavioural Consequences <idrish.ali@monash.edu 4:30PM - 5:00PM 5. Peter A. Tass. Department of Neurosurgery, Stanford University School of Medicine, Stanford, USA. Vibrotactile Fingertip Stimulation for the Treatment of Parkinson’s Disease and Possible Applications to Epilepsy <ptass@stanford.edu> 5:00PM - 6:00PM GENERAL DISCUSSSION 22nd September 8:15AM - 11:15AM Fifth Round Table - Morning Session Neuropathology, Inflammation, Connectomes, Negative and Positive Neuroplasticity Chair: Cristina Ruedell Reschke; Co-Chair: Olagide Wagner de Castro 8:15AM - 8:45AM 1. Rossella Di Sapia. Laboratory of Experimental Neurology - Mario Negri Institute for Pharmacological Research. Milano. Italy. Neuroactive Peptides and Inflammatory Mediators in the Etiopathogenesis of Seizures and their Impact in the Mechanisms of Pharmacoresistance <rossella.disapia@marionegri.it> 8:45AM - 9:15AM 2. Sandra Orozco. Medical Research Unit in Neurological Diseases, Specialty Hospital, National Medical Center, Ciudad de Mexico, Mexico. Assessment of Neuroinflammation in Drug - Resistant Epilepsy: The Role of Autoimmunity <sorozco5@hotmail.com> 9:15AM - 9:45AM 3. Victor Rodrigues Santos. Universidade Federal de Minas Gerais. Belo Horizonte, Brasil. The Treatment of Immature Brain Seizures and Epileptogenesis from the Viewpoint of Cannabinoids <victorrsantos@gmail.com> 9:45AM - 10:15AM COFFEE-BREAK 10:15AM - 10:45AM 4. Maira Licia Foresti - Universidade Federal de São Paulo. São Paulo, Brazil. Modeling of Post-Traumatic Epilepsy and Experimental Research aimed at its Prevention <mairalicia@yahoo.com.br> 10:45AM to 11:15AM 5. Efrain Buriticá. Universidad del Valle. Cali, Colombia. On Post-Traumatic Epilepsies and other Drug-Resistant Epilepsies: In the Search for Biomarkers in Surgical Human Brain Tissue <efrain.buritica@correounivalle.edu.co> 11:15AM - 12:15AM GENERAL DISCUSSION 12:15AM – 2:00PM LUNCH-BREAK 22nd September 2:00PM - 6:00PM Sixth Round Table - Afternoon Session Paradigm Shifts towards Integrative Views in the Research of the Epilepsies and Neuropsychiatric Comorbidities Chair: Prof. Marcio Flávio Dutra Moraes; Co-Chair: Hana Kubová 2:00PM - 2:30PM 1. Candi LaSarge. Department of Anesthesia. Cincinnati Children's Hospital. University of Cincinnati. Cincinnati, USA. mTOR Hyperactivity Initiates an Epileptogenic Cascade <candi.lasarge@cchmc.org> 2:30PM - 3:00PM 2. Ana Carolina Coan. Department of Neurology Universidade de Campinas - UNICAMP. Campinas. Brasil. Mapping the Maze: Navigating the Complex Relationship of Epilepsy, White Matter Integrity, and Neurodevelopmental Impairment. <acoan@unicamp.br> 3:00PM to 3:30PM 3. David-Ahmedt Aristizabal. Imaging and Computer Vision Group CSIRO Data61. Canberra, Australia. Computer Vision for Understanding Patients’ Behavior: A Focus on Epilepsy and other Motor Disorders <david.ahmedtaristizabal@data61.csiro.au> 3:30PM to 4:00PM COFFEE-BREAK 4:00PM - 4:30PM 4. Marcio F.D. Moraes. University of Minas Gerais. Belo Horizonte, Brasil. Changing a Localizationist Brain Architecture View for One of Temporally Organized Packages. The Concept of Coincidence Detectors instead of Integration-Response and its Impact in the Treatment of the Epilepsies <marcionnc@gmail.com> 4:30PM - 5:00PM 5. Norberto Garcia-Cairasco. Ribeirão Preto School of Medicine. University of São Paulo. Ribeirão Preto, Brasil. Challenges to Decipher the Main Intertwined Protagonists of Epileptogenesis and Comorbidities in a Complex Landscape of Semiology, Neuroanatomical Networks, and their Neuroplastic Abnormal Activity <ngcairas@usp.br> 5:00PM-6:00PM GENERAL DISCUSSION 6:00PM to 6:30PM GENERAL REFLEXIONS/FINAL COMMENTARIES 6:30PM to 7:00PM CLOSING REMARKS

Forma de Avaliação:

Ao final do curso, no prazo máximo de 30 dias, deverá ser apresentado um relatório (entre 8 e 10 páginas, sem incluir a bibliografia) sobre uma palestra (de escolha do aluno) contendo um comentário crítico que integre os temas discutidos durante o Symposium NEWroscience.

Type of Assessment:

At the end of the course, within a maximum period of 30 days, a report (between 8-10 pages, not including the references) on a lecture (chosen by the student) must be presented containing a critical comment that integrates the topics discussed during the Symposium NEWroscience.

Observação:

Todas as aulas serão ministradas em inglês. Os alunos deverão fazer a inscrição no Simpósio NEWroscience 2023 que será GRATUITA

Notes/Remarks:

All classes will be taught in English. Students must register for the NEWroscience 2023 Symposium which will be FREE.

Bibliografia:

1. Wolf P. (2016). Epilepsy and metaphors in literature. Epilepsy Behav. Apr;57(Pt B):243-6. 2. Kickhofel E.H.P. (2014). A Philosophiae partitio de Gregor Reisch: Um mapa para ler o Renascimento. REVISTA LIMIAR, v. 3, p. 85 3. . dos Santos R.G.; Sanches R.F., Osorio F.L., Hallak J.E.C. (2018). Long-term effects of ayahuasca in patients with recurrent depression: a 5-year qualitative follow-up. Archives of Clinical Psychiatry (São Paulo), v. 45, p. 22-24. ASTH, Laila; IGLESIAS, Lia P.; DE OLIVEIRA, Antônio C.; MORAES, Marcio F. D.; MOREIRA, Fabrício A. Exploiting cannabinoid and vanilloid mechanisms for epilepsy treatment. Epilepsy & Behavior, [S. l.], v. 121, p. 106832, 2021. DOI: https://doi.org/10.1016/j.yebeh.2019.106832. Disponível em: https://www.sciencedirect.com/science/article/pii/S1525505019303737. AUZMENDI, Jerónimo; AKYUZ, Enes; LAZAROWSKI, Alberto. The role of P-glycoprotein (P-gp) and inwardly rectifying potassium (Kir) channels in sudden unexpected death in epilepsy (SUDEP). Epilepsy & Behavior, [S. l.], v. 121, p. 106590, 2021. DOI: https://doi.org/10.1016/j.yebeh.2019.106590. Disponível em: https://www.sciencedirect.com/science/article/pii/S1525505019307991. CHVOJKA, Jan; KUDLACEK, Jan; CHANG, Wei-Chih; NOVAK, Ondrej; TOMASKA, Filip; OTAHAL, Jakub; JEFFERYS, John G. R.; JIRUSKA, Premysl. The role of interictal discharges in ictogenesis — A dynamical perspective. Epilepsy & Behavior, [S. l.], v. 121, p. 106591, 2021. DOI: https://doi.org/10.1016/j.yebeh.2019.106591. Disponível em: https://www.sciencedirect.com/science/article/pii/S1525505019307383. CLARKE, Shannon et al. Computer-assisted EEG diagnostic review for idiopathic generalized epilepsy. Epilepsy & Behavior, [S. l.], v. 121, p. 106556, 2021. DOI: https://doi.org/10.1016/j.yebeh.2019.106556. Disponível em: https://www.sciencedirect.com/science/article/pii/S1525505019306018. COTA, Vinícius Rosa; DE OLIVEIRA, Jasiara Carla; DAMÁZIO, Laila Cristina Moreira; MORAES, Márcio Flávio Dutra. Nonperiodic stimulation for the treatment of refractory epilepsy: Applications, mechanisms, and novel insights. Epilepsy & Behavior, [S. l.], v. 121, p. 106609, 2021. DOI: https://doi.org/10.1016/j.yebeh.2019.106609. Disponível em: https://www.sciencedirect.com/science/article/pii/S1525505019306237. DOS SANTOS, Rafael Guimarães; HALLAK, Jaime Eduardo Cecilio. Ayahuasca, an ancient substance with traditional and contemporary use in neuropsychiatry and neuroscience. Epilepsy & Behavior, [S. l.], v. 121, p. 106300, 2021. DOI: https://doi.org/10.1016/j.yebeh.2019.04.053. Disponível em: https://www.sciencedirect.com/science/article/pii/S1525505019302513. ENRIQUE, Andrea Verónica; DI IANNI, Mauricio Emiliano; GOICOECHEA, Sofía; LAZAROWSKI, Alberto; VALLE-DORADO, María Guadalupe; COSTA, Juan José López; ROCHA, Luisa; GIRARDI, Elena; TALEVI, Alan. New anticonvulsant candidates prevent P-glycoprotein (P-gp) overexpression in a pharmacoresistant seizure model in mice. Epilepsy & Behavior, [S. l.], v. 121, p. 106451, 2021. DOI: https://doi.org/10.1016/j.yebeh.2019.106451. Disponível em: https://www.sciencedirect.com/science/article/pii/S152550501930441X. GARCIA-CAIRASCO, Norberto; PODOLSKY-GONDIM, Guilherme; TEJADA, Julian. Searching for a paradigm shift in the research on the epilepsies and associated neuropsychiatric comorbidities. From ancient historical knowledge to the challenge of contemporary systems complexity and emergent functions. Epilepsy & Behavior, [S. l.], v. 121, p. 107930, 2021. DOI: https://doi.org/10.1016/j.yebeh.2021.107930. Disponível em: https://www.sciencedirect.com/science/article/pii/S1525505021001645. LYBRAND ZR, GOSWAMI S, HSIEH J. Stem cells: A path towards improved epilepsy therapies. Neuropharmacology. 2020 May 15;168:107781. doi: 10.1016/j.neuropharm.2019.107781. Epub 2019 Sep 17. LEITE, Joao Pereira; PEIXOTO-SANTOS, Jose Eduardo. Glia and extracellular matrix molecules: What are their importance for the electrographic and MRI changes in the epileptogenic zone? Epilepsy & Behavior, [S. l.], v. 121, p. 106542, 2021. DOI: https://doi.org/10.1016/j.yebeh.2019.106542. Disponível em: https://www.sciencedirect.com/science/article/pii/S1525505019305712. LOVISARI, Francesca; SIMONATO, Michele. Gene networks and microRNAs: Promises and challenges for treating epilepsies and their comorbidities. Epilepsy & Behavior, [S. l.], v. 121, p. 106488, 2021. DOI: https://doi.org/10.1016/j.yebeh.2019.106488. Disponível em: https://www.sciencedirect.com/science/article/pii/S1525505019306559. MAGALHÃES, Pedro H. M.; MORAES, Helena T.; ATHIE, Maria C. P.; SECOLIN, Rodrigo; LOPES-CENDES, Iscia. New avenues in molecular genetics for the diagnosis and application of therapeutics to the epilepsies. Epilepsy & Behavior, [S. l.], v. 121, p. 106428, 2021. DOI: https://doi.org/10.1016/j.yebeh.2019.07.029. Disponível em: https://www.sciencedirect.com/science/article/pii/S1525505019304378. MARINCOVICH, Anthony; BRAVO, Eduardo; DLOUHY, Brian; RICHERSON, George B. Amygdala lesions reduce seizure-induced respiratory arrest in DBA/1 mice. Epilepsy & Behavior, [S. l.], v. 121, p. 106440, 2021. DOI: https://doi.org/10.1016/j.yebeh.2019.07.041. Disponível em: https://www.sciencedirect.com/science/article/pii/S1525505019305517. MENDES, Renan Augusto Viana; ZACHARIAS, Leonardo Rakauskas; RUGGIERO, Rafael Naime; LEITE, João Pereira; MORAES, Márcio Flavio Dutra; LOPES-AGUIAR, Cleiton. Hijacking of hippocampal–cortical oscillatory coupling during sleep in temporal lobe epilepsy. Epilepsy & Behavior, [S. l.], v. 121, p. 106608, 2021. DOI: https://doi.org/10.1016/j.yebeh.2019.106608. Disponível em: https://www.sciencedirect.com/science/article/pii/S1525505019308972. MORAES, Márcio Flávio Dutra; DE CASTRO MEDEIROS, Daniel; MOURAO, Flávio Afonso Gonçalves; CANCADO, Sergio Augusto Vieira; COTA, Vinicius Rosa. Epilepsy as a dynamical system, a most needed paradigm shift in epileptology. Epilepsy & Behavior, [S. l.], v. 121, p. 106838, 2021. DOI: https://doi.org/10.1016/j.yebeh.2019.106838. Disponível em: https://www.sciencedirect.com/science/article/pii/S1525505019310777. MOURA, Daniela M. S.; DE SALES, Igor R. P.; BRANDÃO, Juliana A.; COSTA, Marcos R.; QUEIROZ, Claudio M. Disentangling chemical and electrical effects of status epilepticus-induced dentate gyrus abnormalities. Epilepsy & Behavior, [S. l.], v. 121, p. 106575, 2021. DOI: https://doi.org/10.1016/j.yebeh.2019.106575. Disponível em: https://www.sciencedirect.com/science/article/pii/S1525505019305463. PÉREZ-PÉREZ, Daniel; FRÍAS-SORIA, Christian L.; ROCHA, Luisa. Drug-resistant epilepsy: From multiple hypotheses to an integral explanation using preclinical resources. Epilepsy & Behavior, [S. l.], v. 121, p. 106430, 2021. DOI: https://doi.org/10.1016/j.yebeh.2019.07.031. Disponível em: https://www.sciencedirect.com/science/article/pii/S1525505019304408. PITKÄNEN, Asla et al. Biomarkers for posttraumatic epilepsy. Epilepsy & Behavior, [S. l.], v. 121, p. 107080, 2021. DOI: https://doi.org/10.1016/j.yebeh.2020.107080. Disponível em: https://www.sciencedirect.com/science/article/pii/S1525505020302596. RIGHES MARAFIGA, Joseane; VENDRAMIN PASQUETTI, Mayara; CALCAGNOTTO, Maria Elisa. GABAergic interneurons in epilepsy: More than a simple change in inhibition. Epilepsy & Behavior, [S. l.], v. 121, p. 106935, 2021. DOI: https://doi.org/10.1016/j.yebeh.2020.106935. Disponível em: https://www.sciencedirect.com/science/article/pii/S1525505019309175. RONDINONI, Carlo; MAGNUN, Celso; VALLOTA DA SILVA, Alexandre; HEINSEN, Helmut Manfred; AMARO, Edson. Epilepsy under the scope of ultra-high field MRI. Epilepsy & Behavior, [S. l.], v. 121, p. 106366, 2021. DOI: https://doi.org/10.1016/j.yebeh.2019.06.010. Disponível em: https://www.sciencedirect.com/science/article/pii/S1525505019301349. SANTOS, Victor Rodrigues; SANTANA MELO, Igor; PACHECO, Amanda Larissa Dias; DE CASTRO, Olagide Wagner. Life and death in the hippocampus: What’s bad? Epilepsy & Behavior, [S. l.], v. 121, p. 106595, 2021. DOI: https://doi.org/10.1016/j.yebeh.2019.106595. Disponível em: https://www.sciencedirect.com/science/article/pii/S152550501930798X. STRENG, Martha L.; KROOK-MAGNUSON, Esther. The cerebellum and epilepsy. Epilepsy & Behavior, [S. l.], v. 121, p. 106909, 2021. DOI: https://doi.org/10.1016/j.yebeh.2020.106909. Disponível em: https://www.sciencedirect.com/science/article/pii/S1525505019311667. TEJADA, Julian; ROQUE, Antonio C. Conductance-based models and the fragmentation problem: A case study based on hippocampal CA1 pyramidal cell models and epilepsy. Epilepsy & Behavior, [S. l.], v. 121, p. 106841, 2021. DOI: https://doi.org/10.1016/j.yebeh.2019.106841. Disponível em: https://www.sciencedirect.com/science/article/pii/S1525505019310819. TILELLI, Cristiane Queixa; FLÔRES, Larissa Ribeiro; COTA, Vinicius Rosa; DE CASTRO, Olagide Wagner; GARCIA-CAIRASCO, Norberto. Amygdaloid complex anatomopathological findings in animal models of status epilepticus. Epilepsy & Behavior, [S. l.], v. 121, p. 106831, 2021. DOI: https://doi.org/10.1016/j.yebeh.2019.106831. Disponível em: https://www.sciencedirect.com/science/article/pii/S1525505019302823. UPADHYA, Dinesh; SHETTY, Ashok K. Promise of extracellular vesicles for diagnosis and treatment of epilepsy. Epilepsy & Behavior, [S. l.], v. 121, p. 106499, 2021. DOI: https://doi.org/10.1016/j.yebeh.2019.106499. Disponível em: https://www.sciencedirect.com/science/article/pii/S1525505019306146. WOLF, Peter; YACUBIAN, Elza Márcia. The epileptic experience in the works of Dostoyevsky and Machado de Assis. Epilepsy & Behavior, [S. l.], v. 121, p. 106205, 2021. DOI: https://doi.org/10.1016/j.yebeh.2019.03.010. Disponível em: https://www.sciencedirect.com/science/article/pii/S1525505019301337. ZANÃO, Tamires Araujo; LOPES, Tatila Martins; DE CAMPOS, Brunno Machado; YASUDA, Clarissa Lin; CENDES, Fernando. Patterns of default mode network in temporal lobe epilepsy with and without hippocampal sclerosis. Epilepsy & Behavior, [S. l.], v. 121, p. 106523, 2021. DOI: https://doi.org/10.1016/j.yebeh.2019.106523. Disponível em: https://www.sciencedirect.com/science/article/pii/S1525505019303476. FORMA.

Bibliography:

Tipo de oferecimento da disciplina:

Presencial

Class type:

Presencial