Disciplina Discipline VCI5753
Morfofisiologia da Placenta e Placentação
Placenta Morphophysiology of and Placentation

Área de Concentração: 10132

Concentration area: 10132

Criação: 21/12/2022

Creation: 21/12/2022

Ativação: 21/12/2022

Activation: 21/12/2022

Nr. de Créditos: 4

Credits: 4

Carga Horária:

Workload:

Docentes Responsáveis:

Professors:

Maria Angélica Miglino

Durvanei Augusto Maria

Selma Maria de Almeida Santos

Rodrigo da Silva Nunes Barreto

Objetivos:

Esta disciplina objetiva fornecer aos alunos de Pós-Graduação conhecimentos que lhes permita reconhecer as diferentes formas de classificação placentária e seus exemplos na natureza, bem como a arquitetura placentária e das membranas fetais e suas implicações funcionais. Tanto animais domésticos quanto silvestres são abordados nesta temática visando o completo conhecimento do órgão.

Objectives:

This discipline aims to provide graduate students with knowledge that allows them to recognize the different forms of placental classification and their examples in nature, as well as placental architecture fetal membranes and their functional implications. Both domestic and wild animals are addressed in this theme aiming at the complete knowledge of the organ.

Justificativa:

Nos diferentes animais domésticos, de modo geral, a placenta é corialantóide e a compreensão dos mecanismos envolvidos nos processos de trocas fisiológicas entre mãe e feto, passam pelo conhecimento anatômico, pela complexidade e variedade estrutural encontrada entre as diferentes espécies.

Rationale:

In the different domestic animals, in general, the placenta is corialantoid and the understanding of the mechanisms involved in the processes of physiological exchanges between mother and fetus, depends on anatomical knowledge, complexity and structural variety found between the differents species.

Conteúdo:

1. Aspectos históricos da placenta e placentação; 2. Classificação das placentas: análise crítica. Estudo microscópico das placentas e suas relações funcionais; 3. Componentes morfológicos do ovo; 4. A oviparidade e a transição para a viviparidade placentária; 5. Classificação atual dos modelos de placentação; 6. Aspectos anatômicos e funcionais da circulação da placenta e fluxo placentário; 7. Circulação materno-fetal (fetal, vitelínica e placentária); 8. Técnicas de investigação em microcirculação placentária; 9. Origem e desenvolvimento do trofoblasto; 10. Implantação embrionária em animais com placentas: epiteliocorial, sinepiteliocorial, endoteliocorial e hemo-coriais; 11. Parâmetros fisiológicos da gestação; 12. Papel da matriz extra-celular na fisiologia do trofoblasto; 13. Métodos quantitativos aplicados a placenta; 14. Estatística Básica; 15. Metodologia básica para Revisão Sistemática.

Content:

1. Historical aspects of placenta and placentation; 2. Classification of placentas: critical analysis. Microscopic study of placentas and their functional relationships; 3. Morphological components of the egg; 4. Oviparity and the transition to placental viviparity; 5. Current classification of placental models; 6. Anatomical and functional aspects of placental circulation and placental flow; 7. Maternal-fetal circulation (fetal, vitellenic and placental); 8. Research techniques in placental microcirculation; 9. Origin and development of trophoblast; 10. Embryonic implantation in animals with placentas: epitheliocorial, sinepitheliocorial, endotheliocorial and hemo-corial; 11. Physiological parameters of pregnancy; 12. Role of extracellular matrix in trophoblast physiology; 13. Quantitative methods applied to placenta; 14. Basic Statistics; 15. Basic methodology for Systematic Review.

Forma de Avaliação:

Seminários finais (1ª nota = 0-10) e discussões em grupos (2ª nota = 0-10). Relação nota/conceito, com média simples entre os critérios de avaliação: 10-9/A, 8-7/B, 6-5/C, 4-0/R.

Type of Assessment:

Final seminars (1st grade = 0-10) and group discussions (2nd grade = 0-10). Note/concept ratio, with simple average among the evaluation criteria: 10-9/A, 8-7/B, 6-5/C, 4-0/R.

Bibliografia:

1. Aplin, J.D. 1996. The cell biology of human implantation. Placenta, 269-275. 2. Bergh. P. & Navot, D. 1992. The impact of embryonic development and endometrial maturity on the timing of implantation. Fertility and Sterility, 58:537-542. 3. BORDIGNON, V.; SMITH, L. Clonagem animal por transferência nuclear. In: GONÇALVES, P.B.D.; FIGUEIREDO, J.R.; FREITAS, V.J.F. Biotécnicas aplicadas à reprodução animal. São Paulo: Varela, 2002. p. 281-303. 4. Campbell, S.; Swann, H.; Seif,M.; Kimber, S. & Aplin, J.D. 1995. Cell adhesion molecules on theoocyte and pre-implantation human embryo. Molecular Human Reproduction, 1:1571-1576. 5. CARAMBULA, S.; MIGLINO, M.A.; DIDIO, L.J.A.; TEIXEIRA FILHO, A.; SOUZA, W.M. Pesquisa anatômica sobre a ramificação e disposição das artérias e veias das placentas de bovinos azebuados. Brazilian Journal of Veterinary Research and Animal Science, v. 34,n. 3-4, 1997. 6. CONSTÂNCIA, M.; HEMBERGER†, M.; HUGHES, J.; DEAN, W.; SMITH, A.F.; FUNDELE, R.; STEWART, F.; KELSEY, G.; FOWDENK; A.; SIBLEY, C.; REIK, W. Placental-specific IGF-II is a major modulator of placental and fetal growth. Nature, vol. 417, June 2002. 7. DINNYÉS, A.; SOUSA, P.; KING, T.; WILMUT, I. Somatic cell nuclear transfer: recent progress and challenges. Cloning and stem cells, v. 4, n. 1, 2002. 8. EXLEY, G.E.; WARNER, C.M. Selection in favor of the Ped fast haplotype occurs between mid-gestation and birth. Immunogenetics, v.49, n.7-8, p. 653-659, 1999. 9. HEYMAN, Y.; CHAVATTE-PALMER, P.; LEBOURHIS, D.; CAMOUS, S.; VIGNON, X.; RENARD, J.P. Frequency and occurrence of late-gestation losses from cattle cloned embryos. Biol. Reprod., 66, 6-13, 2002. 10. HILL, J.R., BURGHARDT, R.C., JONES, K., et al. (2000). Evidence for placental abnormality as the major cause of mortality in first-trimester somatic cell cloned bovine fetuses. Biol. Reprod., 63, 1787–1794. 11. HILL, J.R., ROUSSEL, A.J., CIBELLI, J.B., EDWARDS, J.F., HOOPER, N.L., MILLER, M.W., THOMPSON, J.A., LOONEY, C.R., WESTHUSIN, M.E., ROB, J.M., STICE S.L. Clinical and pathological features of cloned transgenic calves and fetuses (13 cases studies). Theriogenology, 51:1451-1465, 1999. 12. KATHIRESAN, R.; RAJASUNDARAM, R. C.; PATTABIRAMAN, S. R. Histological and histochemical changes in the endometrium and placenta during different stages of gestation in buffaloes (Bubalus bubalis). Indian Veterinary Journal, v. 69, april, p. 326–328, 1992. 13. LEISER, R.; KAUFMANN, P. Placental structure: in a comparative aspect. Exp. Clin. Endocrinal. 1994. p. 122-134. 14. MEIRELLES, F.V., BORDIGNON, V., WATANABE, Y., et al. Complete replacement of the mitochondrial genotype in a Bos indicus calf reconstructed by nuclear transfer to a Bos taurus oocyte. Genetics, 158, 351–356, 2001. 15. MIGLINO, M.A. Pesquisa anatômica sobre artérias e veias do cordão umbilical, sua ramificação e disposição na placenta de bovinos. São Paulo, 1991. Tese (Livre Docência) Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo. 16. NIEMANN, H.; WRENZYCKI, C.; LUCAS-HAHN, A.; BRAMBRINK, T.; KUES, W.A.; CARNWATH; J.W. Gene expression patterns in bovine in vitro - produced and nuclear transfer - derived embryos and their implications for early development. Cloning and stem cells, v. 4, n. 1, 2002. 17. PAMPFER, S.; DONNAY, I. Apoptosis at the time of embryo implantation in mouse and rat. Cell Death and Differentiation, v.6, p. 533-545, 1999. 18. Soares, M. J.; Chapman, B.; Rasmussen, C.; Daí, G.; Kamei, T. & Orwig, K. 1996. Differentiation of trophoblast endocrine cells. Placenta, 17:277-289. 19. Yelian, F.D., Yang, Y., Hirata, J.D.; Schultz, J.F. & Armant, D.R. 1995. Molecular interactions between fibronectin and integrins during mouse blastocyst outgrowth. Molecular Reproduction and Development, 41:435-448. 20. Yang, C., Song, G., & Lim, W. (2019). A mechanism for the effect of endocrine disrupting chemicals on placentation. Chemosphere, 231, 326-336. 21. Perez-Garcia, V., Fineberg, E., Wilson, R., Murray, A., Mazzeo, C. I., Tudor, C., ... & Hemberger, M. (2018). Placentation defects are highly prevalent in embryonic lethal mouse mutants. Nature, 555(7697), 463-468. 22. Johnson, G. A., Bazer, F. W., & Seo, H. (2021). The early stages of implantation and placentation in the pig. In Placentation in Mammals (pp. 61-89). Springer, Cham. 23. Seo, H., Bazer, F. W., Burghardt, R. C., & Johnson, G. A. (2019). Immunohistochemical examination of trophoblast syncytialization during early placentation in sheep. International journal of molecular sciences, 20(18), 4530. 24. Soares, M. J., Varberg, K. M., & Iqbal, K. (2018). Hemochorial placentation: development, function, and adaptations. Biology of reproduction, 99(1), 196-211. 25. Adu-Gyamfi, E. A., Ding, Y. B., & Wang, Y. X. (2020). Regulation of placentation by the transforming growth factor beta superfamily. Biology of Reproduction, 102(1), 18-26. 26. Fujiwara, H., Ono, M., Sato, Y., Imakawa, K., Iizuka, T., Kagami, K., ... & Araki, Y. (2020). Promoting roles of embryonic signals in embryo implantation and placentation in cooperation with endocrine and immune systems. International Journal of Molecular Sciences, 21(5), 1885. 27. Senapati, S., Wang, F., Ord, T., Coutifaris, C., Feng, R., & Mainigi, M. (2018). Superovulation alters the expression of endometrial genes critical to tissue remodeling and placentation. Journal of Assisted Reproduction and Genetics, 35(10), 1799-1808. 28. Stenhouse, C., Seo, H., Wu, G., Johnson, G. A., & Bazer, F. W. (2022). Insights into the regulation of implantation and placentation in humans, rodents, sheep, and pigs. Recent Advances in Animal Nutrition and Metabolism, 25-48. 29. Blackburn, D. G and Stewart, J.R. Viviparity and Placentation in Reproductive Biology and Phylogeny of Snakes, 2011.

Bibliography:

1. Aplin, J.D. 1996. The cell biology of human implantation. Placenta, 269-275. 2. Bergh. P. & Navot, D. 1992. The impact of embryonic development and endometrial maturity on the timing of implantation. Fertility and Sterility, 58:537-542. 3. BORDIGNON, V.; SMITH, L. Clonagem animal por transferência nuclear. In: GONÇALVES, P.B.D.; FIGUEIREDO, J.R.; FREITAS, V.J.F. Biotécnicas aplicadas à reprodução animal. São Paulo: Varela, 2002. p. 281-303. 4. Campbell, S.; Swann, H.; Seif,M.; Kimber, S. & Aplin, J.D. 1995. Cell adhesion molecules on theoocyte and pre-implantation human embryo. Molecular Human Reproduction, 1:1571-1576. 5. CARAMBULA, S.; MIGLINO, M.A.; DIDIO, L.J.A.; TEIXEIRA FILHO, A.; SOUZA, W.M. Pesquisa anatômica sobre a ramificação e disposição das artérias e veias das placentas de bovinos azebuados. Brazilian Journal of Veterinary Research and Animal Science, v. 34,n. 3-4, 1997. 6. CONSTÂNCIA, M.; HEMBERGER†, M.; HUGHES, J.; DEAN, W.; SMITH, A.F.; FUNDELE, R.; STEWART, F.; KELSEY, G.; FOWDENK; A.; SIBLEY, C.; REIK, W. Placental-specific IGF-II is a major modulator of placental and fetal growth. Nature, vol. 417, June 2002. 7. DINNYÉS, A.; SOUSA, P.; KING, T.; WILMUT, I. Somatic cell nuclear transfer: recent progress and challenges. Cloning and stem cells, v. 4, n. 1, 2002. 8. EXLEY, G.E.; WARNER, C.M. Selection in favor of the Ped fast haplotype occurs between mid-gestation and birth. Immunogenetics, v.49, n.7-8, p. 653-659, 1999. 9. HEYMAN, Y.; CHAVATTE-PALMER, P.; LEBOURHIS, D.; CAMOUS, S.; VIGNON, X.; RENARD, J.P. Frequency and occurrence of late-gestation losses from cattle cloned embryos. Biol. Reprod., 66, 6-13, 2002. 10. HILL, J.R., BURGHARDT, R.C., JONES, K., et al. (2000). Evidence for placental abnormality as the major cause of mortality in first-trimester somatic cell cloned bovine fetuses. Biol. Reprod., 63, 1787–1794. 11. HILL, J.R., ROUSSEL, A.J., CIBELLI, J.B., EDWARDS, J.F., HOOPER, N.L., MILLER, M.W., THOMPSON, J.A., LOONEY, C.R., WESTHUSIN, M.E., ROB, J.M., STICE S.L. Clinical and pathological features of cloned transgenic calves and fetuses (13 cases studies). Theriogenology, 51:1451-1465, 1999. 12. KATHIRESAN, R.; RAJASUNDARAM, R. C.; PATTABIRAMAN, S. R. Histological and histochemical changes in the endometrium and placenta during different stages of gestation in buffaloes (Bubalus bubalis). Indian Veterinary Journal, v. 69, april, p. 326–328, 1992. 13. LEISER, R.; KAUFMANN, P. Placental structure: in a comparative aspect. Exp. Clin. Endocrinal. 1994. p. 122-134. 14. MEIRELLES, F.V., BORDIGNON, V., WATANABE, Y., et al. Complete replacement of the mitochondrial genotype in a Bos indicus calf reconstructed by nuclear transfer to a Bos taurus oocyte. Genetics, 158, 351–356, 2001. 15. MIGLINO, M.A. Pesquisa anatômica sobre artérias e veias do cordão umbilical, sua ramificação e disposição na placenta de bovinos. São Paulo, 1991. Tese (Livre Docência) Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo. 16. NIEMANN, H.; WRENZYCKI, C.; LUCAS-HAHN, A.; BRAMBRINK, T.; KUES, W.A.; CARNWATH; J.W. Gene expression patterns in bovine in vitro - produced and nuclear transfer - derived embryos and their implications for early development. Cloning and stem cells, v. 4, n. 1, 2002. 17. PAMPFER, S.; DONNAY, I. Apoptosis at the time of embryo implantation in mouse and rat. Cell Death and Differentiation, v.6, p. 533-545, 1999. 18. Soares, M. J.; Chapman, B.; Rasmussen, C.; Daí, G.; Kamei, T. & Orwig, K. 1996. Differentiation of trophoblast endocrine cells. Placenta, 17:277-289. 19. Yelian, F.D., Yang, Y., Hirata, J.D.; Schultz, J.F. & Armant, D.R. 1995. Molecular interactions between fibronectin and integrins during mouse blastocyst outgrowth. Molecular Reproduction and Development, 41:435-448. 20. Yang, C., Song, G., & Lim, W. (2019). A mechanism for the effect of endocrine disrupting chemicals on placentation. Chemosphere, 231, 326-336. 21. Perez-Garcia, V., Fineberg, E., Wilson, R., Murray, A., Mazzeo, C. I., Tudor, C., ... & Hemberger, M. (2018). Placentation defects are highly prevalent in embryonic lethal mouse mutants. Nature, 555(7697), 463-468. 22. Johnson, G. A., Bazer, F. W., & Seo, H. (2021). The early stages of implantation and placentation in the pig. In Placentation in Mammals (pp. 61-89). Springer, Cham. 23. Seo, H., Bazer, F. W., Burghardt, R. C., & Johnson, G. A. (2019). Immunohistochemical examination of trophoblast syncytialization during early placentation in sheep. International journal of molecular sciences, 20(18), 4530. 24. Soares, M. J., Varberg, K. M., & Iqbal, K. (2018). Hemochorial placentation: development, function, and adaptations. Biology of reproduction, 99(1), 196-211. 25. Adu-Gyamfi, E. A., Ding, Y. B., & Wang, Y. X. (2020). Regulation of placentation by the transforming growth factor beta superfamily. Biology of Reproduction, 102(1), 18-26. 26. Fujiwara, H., Ono, M., Sato, Y., Imakawa, K., Iizuka, T., Kagami, K., ... & Araki, Y. (2020). Promoting roles of embryonic signals in embryo implantation and placentation in cooperation with endocrine and immune systems. International Journal of Molecular Sciences, 21(5), 1885. 27. Senapati, S., Wang, F., Ord, T., Coutifaris, C., Feng, R., & Mainigi, M. (2018). Superovulation alters the expression of endometrial genes critical to tissue remodeling and placentation. Journal of Assisted Reproduction and Genetics, 35(10), 1799-1808. 28. Stenhouse, C., Seo, H., Wu, G., Johnson, G. A., & Bazer, F. W. (2022). Insights into the regulation of implantation and placentation in humans, rodents, sheep, and pigs. Recent Advances in Animal Nutrition and Metabolism, 25-48. 29. Blackburn, D. G and Stewart, J.R. Viviparity and Placentation in Reproductive Biology and Phylogeny of Snakes, 2011.

Tipo de oferecimento da disciplina:

Presencial

Class type:

Presencial