THIS COURSE WILL BE TAUGHT ENTIRELY IN ENGLISH. It is expected that the undergraduate students develop competency in the activities covering the development and characterization of nanostructures aiming to obtain innovative products. The discipline will also allow the student to acquire skills in the preparation of different nanostructures. In addition, current regulations and the ethical aspects of nanotechnology applied to health sciences will be discussed.
Basic definitions: nanoscience and nanotechnology. Development and characterization of matrix and non-matrix nanostructures. Industrial scale methods in the manufacturing of nanostructured systems. Regulatory and ethical aspects of nanotechnology. Modified drug and bioactive release systems: opportunities and challenges.
Theoretical: 1. Definitions and fundamentals: nanoscience and nanotechnology; 2. Properties of nanometer-scale materials: quantum confinement effects, properties due to size and surface effects; 3. Techniques of preparation of nanostructures (ascending and descending); 4. Techniques of physical-chemical and morphological characterization of nanostructures; 5. Regulatory and ethical aspects of nanotechnology applied to health sciences; 6. Innovation, patent and intellectual property. Laboratory: 1. Preparation and physical-chemical characterization of nanostructured lipid systems; 2. Preparation and physical-chemical characterization of nanocrystals of poorly soluble drugs in water.
TOMA, HENRIQUE. E. Nanotecnologia molecular – materiais e dispositivos: 1. ed. São Paulo: Editora Blucher, 2016. KUMAR, A.; HEIDI, M.M.; FRIEDMAN, A.; BLOUGH, E.R. Nanomedicine in Drug Delivery: 1. ed. Boca Raton, Florida: CRC Press, 2013. McNEIL, E. S. Characterization of nanoparticles intended for drug delivery. 1 ed. London: Humana Press, 2011. HUNTER, R.J.; PREEDY, V.R. Nanomedicine in health and disease. 1 ed. St. Helier: Science Publishers, 2011. MONTEIRO, L.M.; LÖBENBERG, R.; COTRIM, P.C.A.; GABRIEL, L.B. and BOU-CHACRA, N.A. Buparvaquone Nanostructured Lipid Carrier: Development of an Affordable Delivery System for the Treatment of Leishmaniases. BioMed Research International. V. 2017, p.1-11, 2017. YUKUYAMA, M.N.; KATO, E.M.; LÖBENBERG, R.; BOU-CHACRA, N. A. Challenges and future prospects of nanoemulsion as a drug delivery system. Current Pharmaceutical Design, v. 23(3), p. 495-508, 2017. DARIO, MICHELLI F.; SANTOS, M.; SOLEDADE C.S.; VIANA, A. S.; ARÊAS, ELIZABETH P.G.; BOU-CHACRA, N.A.; OLIVEIRA, M. C. ; DA PIEDADE, M.E.M.; BABY, A.R.; VELASCO, M.V.R. A high loaded cationic nanoemulsion for quercetin delivery obtained by sub-PIT method. Colloids and Surfaces. A, Physicochemical and Engineering Aspects, v. 489, p. 256-264, 2016. BOU-CHACRA, N.A.; HIGUCHI, M. L.; SOUSA, E. C. P.; KAWAKAMI, J. T. Characterization of organic nanoparticles for the production of the topical medications. Global Journal of Engineering Science and Research Management, v. 3, p. 107, 2016. SARFRAZ, M.; ROA, W.; BOU-CHACRA, N.A.; LÖBENBERG, R. Inflammation caused by nanosized delivery systems: is there a benefit? Molecular Pharmaceutics, v. 13, p. 3270-3278, 2016. LI, X.; KECK, C.; MULLER, R.; BOU-CHACRA, N.A. Mucoadhesive dexamethasone acetate-polymyxin B sulfate cationic ocular nanoemulsion--novel combinatorial formulation concept.. Die Pharmazie (Berlin), v. 71, p. 3-333, 2016. ROMERO, G.B.; KECK, C.M.; MÜLLER, R.H.; BOU-CHACRA, N.A. Development of cationic nanocrystals for ocular delivery. European Journal of Pharmaceutics and Biopharmaceutics, v. 107, p. 215-222, 2016. YUKUYAMA, M.N.; GHISLENI, D.D.M.; PINTO, T.J.A.; BOU-CHACRA, N.A. Nanoemulsion: process selection and application in cosmetics - A Review. International Journal of Cosmetic Science, v. 38, p. 13-24, 2016. BOU-CHACRA, N. A.; LOURENÇO, F. R.; LÖBENBERG, R.; LEMES, M. R. S. E.; PINTO, T. J. A. Design space approach for preservative system optimization of an anti-aging eye fluid emulsion. Journal of Pharmacy & Pharmaceutical Sciences, v. 18, p. 551-561, 2015.
