the discipline will provide to the students the basis on clinical pharmacokinetics and its application on dose adjustment required to reach the therapeutic target in critical hospitalized patients.
LADMER systems. Drug-receptor interations. Absorption/Transport Mechanisms GPP. Binding of drugs. Compartment open models. Biotransformation, first pass effect and excretion of drugs, urinary and biliary recycling. Pharmacokinetics of multiple dosing. Drug plasma monitoring and dose adjustment requirements based on PK/PD Models. Extracorporeal methods of drug removal. Polymorphisms in cardiovascular medicine.
1. LADMER systems. 2. Drug-receptor interations. 3. Absorption/Transport Mechanisms GPP. 4. Binding of drugs. 5. Compartment open models. 6. Biotransformation, first pass effect and excretion of drugs, urinary and biliary recycling. 7. Pharmacokinetics of multiple dosing. 8. Drug plasma monitoring and dose adjustment requirements based on PK/PD Models. 9. Extracorporeal methods of drug removal. 10. Polymorphisms in cardiovascular medicine. Students must have knowledge of basic pharmacology, calculus. A basic knowledge of cellular biology, physiology, fundamental biochemistry is desirable. Fifty percent of the grade will be based on practice sets including review questions and discussion points in group of students and one seminar will be presented to complete 100% on evaluation for each student.
DIPIRO, J.T. et al. Concepts in clinical pharmacokinetics. 4rd ed. Stanford: American Society of Health Pharmacists, Inc., Bethesda, 2005. Web-based version is also available.HALL, I.P. & PIRMOHAMED, M. Pharmacogenetics. Taylor & Francis Group , 2006, NY, USA.LIPSCOMB, J.C. & OHANIAN, E.V. Toxicokinetics and Risk Assessment. I nforma healthcare, New York, London, 2007.RITSCHEL, W.A. - Handbook of basic pharmacokinetics – 7th ed. - Apha, American Pharmacists Association, Washington, D.C., USA, 2009.Search on PUBMED to complement the seminars.
