Discipline will provide to the students advanced tools to apply to the control of severe infections in critically ill hospitalized patients with sepsis based on pharmacokinetics (in vivo measurements) obtained by antimicrobial kinetic parameters from a patient and the pharmacodynamics based on in vitro measurements expressed by the minimum inhibitory concentration required to kill 90% of pathogens isolated from fluids and secretions collected from infected hospitalized patients.
Antimicrobial kinetic changes in critically ill hospitalized patients in sepsis. Antimicrobial plasma monitoring and clinical pharmacokinetics in burns. Assessment of the minimum inhibitory concentration by testing the susceptibility of pathogens to antimicrobial agents. Physiopathological changes and factors related to PK and PD variability’s. 5. Pharmacokinetic-pharmacodynamic correlation. Predictive index for antimicrobial effectiveness. Desired outcome by antimicrobial target attainment. Control of nosocomial infections in critically ill patients by application of PK/PD correlation.
1. Antimicrobial kinetic changes in critically ill hospitalized patients in sepsis. 2. Antimicrobial plasma monitoring and clinical pharmacokinetics in burns. 3. Assessment of the minimum inhibitory concentration by testing the susceptibility of pathogens to antimicrobial agents. 4. Physiopathological changes and factors related to PK and PD variability’s. 5. Pharmacokinetic-pharmacodynamic correlation. 5. Predictive index for antimicrobial effectiveness. 6. Desired outcome by antimicrobial target attainment. 7. Control of nosocomial infections in critically ill patients by application of PK/PD correlation. Students must have knowledge of basic pharmacokinetics. A basic knowledge of pharmacotherapy of nosocomial microbial and fungal infections, physiopathology and haemodynamic changes in critically ill patients is desirable. Fifty percent of the grade will be based on practice sets including review questions and discussion points in group of students and one seminar will be presented to complete 100% on evaluation for each student.
SANCHES-GIRAUD, C. et al Antimicrobial therapeutic plasma monitoring by applying PK/PD in burn patients. http://www.formatex.info/microbiology4. Chapter 167 in Antimicrobial - Microbiology: “Microbial Pathogens and strategies for combating them: Science, Technology, Education” Book Series v.23, 2013, ICAR 2012, Mendez-Vilas Editor, Formatex, Baldajoz, Spain.SCHWINGHAMMER,T.L. – Pharmacotherapy case book a patient focuses approach, New York, McGraw-Hikk Medical Pub, D.U., 2005Search on PUBMED to complement the seminars.