Informações da Disciplina

 Preparar para impressão 

Júpiter - Sistema de Gestão Acadêmica da Pró-Reitoria de Graduação


Faculdade de Medicina Veterinária e Zootecnia
 
Nutrição e Produção Animal
 
Disciplina: VNP0241 - Tópicos Avançados em Genética Veterinária
Advanced Topics in Veterinay Genetics

Créditos Aula: 2
Créditos Trabalho: 0
Carga Horária Total: 30 h
Tipo: Semestral
Ativação: 01/01/2006 Desativação:

Objetivos
Discutir através de aulas formais, seminários e visitas técnicas, os principais processos envolvidos na Genética Animal com ênfase na Medicina Veterinária. Fornecer aos alunos os elementos básicos por identificação dos diferentes parâmetros genéticos.
 
 
 
Docente(s) Responsável(eis)
83636 - Maria de Fatima Martins
 
Programa Resumido
Discutir através de aulas formais, seminários e visitas técnicas, os principais processos envolvidos na Genética Animal com ênfase na Medicina Veterinária. Fornecer aos alunos os elementos básicos por identificação dos diferentes parâmetros genéticos
 
 
 
Programa
Módulo citogenético                                                                         a) Divisão celular.                                                                             b) Cromossomos e genes.                                                                c) Divisões cromossômicas irregulares.                                              d) Cariótipo.                                                                                     e) Reprodução - Gametogênese - Fecundação.                                   f) Principais doenças da esfera reprodutiva de etiologia genética.       Citogenética do embrião                                                                   a) Aborto                                                                                        b) Mal formação (congênitas - hereditárias)                                         Genética Molecular                                                                          a) Modernas técnicas de micromanipulação - gametas- embrião- animais transgênicos- aplicação da PCR7.                                          Imunogenética                                                                               a) Anticorpos monoclonais.                                                               b) Produção de vacinas por tecnologia do DNA recombinante.               Resistência genética à doenças                                                       a) Rinite atrófica.                                                                             b) Neoplasias.                                                                                  c) Leucose bovina.                                                                           d) Leucose em outras espécies.                                                        e) Colibaciloses e suas implicações imunogenéticas.                          f) BLAD                                                                                        Genética do escargot Achatina fulica e seu potencial como criação        alternativa na Produção Animal.
 
 
 
Avaliação
     
Método
Aulas teóricas, práticas, seminários, debates e desenvolvimento de projetos
Critério
Provas - Seminários - Grupos de discussão
Norma de Recuperação
A recuperação constará de duas provas, cuja natureza ficará a cargo de cada disciplina, a serem realizadas até uma semana antes do término do período de retificação de matrícula (estabelecido anualmente pelo Calendário USP)
A média da avaliação final da disciplina entrará no computo da recuperação, sendo:
média = média da avaliação final + média da recuperação ÷ 2
 
Bibliografia
     
ABT, D.A.; MARSHAK, R.R.; KULP, H.W.; POLLOCK, R.J.Jr. (1970). Studies on the relationship between limphocytosis and bovine leukosis. Bibliotheca Haematologica: 36: 527-36.ANDERSON, W.F.; DIACUMAKAS, E.G. (1981). Genetic engineering in mammaliam cells. Scientific Amer. 245: 106-21.ANDERSON, W.F. (1984). Prospects for human gene therapy, Science, 226: 401-409.ANDERSON, W., (1985) Genetic Engineering of animals. In: Genetic Engineering of Animal, 315 pp.ANDERSON, G.B. (1985) Manipulation of the mammalian Embryo. Journal of Animal Science, 61: (Suppl.) 3.ANDERSON, L.; BOHME, J.; RASK, L.; PETERSON, P.A. (1986). Genomic hybridization of bovine class II major histocompability genes: 1. Extensive polymorphism of genes. Animal Genetics, 17: 95-112.ANONYMOUS (1982). Proceedings of the second international bovine lymphocyte antigen (BOLA) Workshop. Animal Bload Grups and Biochemical Genetics. 13: 33-53.BELE, B.R.; Mc DANIEL, B.T.; ROBINSON, D.W. (1985). Effects of cytoplasmic inheritance on production traits of dairy cattle. J. Dairy Sci., 68: 2038.BEACH, P.A.; HELFAND, S.L.; HOGNES, D.S. (1985). Segmental distribution of bithorax complex proteins during Drosophila development. Nature, 313: 545-551.BERG, P. (1981). Dissections and reconstruction of genes and chromosomes. Science. 213: 296-303.BISHOP, J.M. (1985). Trends in oncogenes. Trends in Genetic. 1: 245-49.BOOMAN, P. (1986). Control of sex ratio by sexing sperm and embryos. In: Exploiting new Tecnologies in animal breeding. Genetic Development, 202 pp.BRINSTER, R.L.; CHEN, H.Y.; MESSING, A.; VANDIKE, T.; LEVINE, A.J.; PALMITER, R.D. (1984). Transgenic mice harbouring SV40T. Genes development characteristics brain tumours. Cell, 37: 367-79.CHADA, K.; MAGRAM, J.; RAPHAEL, K.; RADICE, G.; LACY, E.; CONSTANTINI, F. (1985). Specific expression of a foreign B globin gene in eveythroid cells of transgenic mice. Nature, 314: 377-80.CHEN, H.Y.; WARREN, R.; SARTHY, A.; PALMITER, R.D. (1982). Regulation of metallothionein-thymidine kinase fusion plasmids injected into mouse eggs. Nature, 296: 39-42.CONSTANTINI, F.; LACY, E. (1981). Introduction of a rabbit B globin gene into the mouse germ line. Nature, 294: 92-4.CONSTANTINI, F. & RACY, E. (1981). Introduction of a rabbit B globin gene into the mouse germ line. Nature, 294: 324.CLINE, M.J.H.; STAND, K.; MERCOLA, L.; MORSE, R.; RUPRECHT, J.; BROWNE.; SALSER, W. (1980). Gene transfer in intact animals. Nature, 284: 422-425.COLLEAU, J.J. (1985). Genetic improvement by embryo transfer with selection nuclei in dairy cattle. Genet. Sel. Evol., 17: 499-539.CHRISTENSEN, L.G.; HIBORIUSSEN, H.R. (1986). Embryo transfer in the genetic improvment of dairy cattle. In: Exploiting new tecnologies in animal breeding. Genetic Development, 202 pp.DAVIES, K.E. (1985). New hypervariable DNA markers for mapping human genetic disease. Trends in Genetics, 1: 97-98.DI BERNARDINO, D.; LIOI, M.B.; CAPRIANO, F.; IANNUZZI, L.; BURGUETE, I.; MATASSINO, D. (1986). Cytogenetic analysis of embryos. In: Exploiting new tecnologies in animal breeding. Genetic Development, 202 pp.DI BERNARDINO, D.; IANNUZZI, L. (1982). Delailed description of R. banded bovine chromosomes. J. Hered., 73: 434-8.FEHILLY, C.B.; WILLADSEN, S.M. & TUCKER, E.M. (1984). Interspecific chimerism between sheep and goats. Nature, 307: 634-636.GRAF, L.H. (1982). Gene transformation. Amer. Scient., 70: 496-505.GANNAN, F. (1986). Transgenic. In: Exploiting new tecnologies in animal breeding development, 202 pp.GARTNER, R. & BAUNACK, E. (1981). Is the similary of monozigotic twins due to genetic factors alone? Nature, 292: 646.GURDON, J.B. (1986). Transolanted nuclei and cell differentiation. Scient. Amer., (Dec), 219: 24-35.FORSTER, M. (1986). Somatic cell genetics and animal breeding. In: Explaiting news tecnologies in animal breeding. Genetic Development, 202 pp.HAMMER, R.E.; PURSEL, V.G.; REXROAD, C.E.Jr.; WALL, R.J.; BOLT, D.J.; CEBERT, K.M.; PALMITER, R. & BRINSTER, R.L. (1985). Production of transgenic rabbits, sheep and pigs by microinjection. Nature, 315: 680-3.HOLCENBERG, J.S. (1982). Enzyme therapy problems and solutions. An. Rev. Biochem., 51: 795-812.HOONG-XUAN, M.; LEVEZIEL, H.; ZIBER, N.T.; LEVY, D. (1982b). Immunochemical characterization of major histocompatibility antigens in cattle. Immunogenetics, 15: 621-4.JOHNSON, M.H.; CHISHOLM, T.P.; FLEMING, T.P.; HOULISTOW, E. (1986). A role for cytoplasmic determinants in the development of the mouse early embryo. J. Embryo. Morph., (Suppl.): 97-121.KLUG, W.S.; CUMMINGS, M.R. (1987). Somatic cell genetics. In: concepts of genetics, 2nd ed., 609 pp.KING, W.A. (1983). Cytogenetics of embryos, application to livestock industry. Proc. 2nd Symp. Adv. Top. Anim. Reprod., 8-11 August, Jaboticabal, Brasil.KLUG, W.S.; CUMMINGS, M.R. (1987). The role of genes in development. In: Concepts of genetics, 2nd ed., 609 pp.KLUG, W.S.; CUMMINGS, M.R. (1987). Extrochromossomal inheritance. In: concepts of genetics, 2nd ed., 699 pp.KLUG, W.S.; CUMMINGS, M.R. (1987). Recombinant DNA: Tecnology and Aplications. In: concepts of genetics, 2nd ed., 609 pp.LEWIN, H.A. (1986). Bernoco D. Evidence for BOLA-Linked resistence and susceptibility to subclinical progression of bovine leukaemia virus infection. Animal Genetics, 17: 197-207.LEDER, P. (1982). The genetics of antibody diversity. Scientific American, 246 (5): 72-83.LEVINE, M.; RUBIN, G.; TJIAN, R. (1984). Human DNA sequences homologous to a protein coding region conserved between homoetic genes of Drosophila. Cell., 38: 667-73.LOBO, R.B. (1980). Genetic Implications of Embryo Transfer -T¢picos Avan‡ados em Reprodu‡Æo Animal, pg. 159-162.LURANI, M.A.H.; REIK, L.W.; NORRIS, M.L.; BARTON, S.C. (1986). Influence of germline modifications of homologous chromosomes on mouse development. J. Embryol. Exp. Morphol. (Suppl), 123-136.MANN, R.; MULLIGAN, R.C.; BATTIMORE, D. (1983). Construction of a retreovirus packagin mutant and its use to produce helper-free defective retrovirus. Cell., 33: 153-159.Mc GRATH, J.; SOLTER, D. (1986). N£cleo citoplasmatic interations in the mouse. J. Embriol. Exp. Morphol. (Suppl). 277-289.Mc GRATH, J. & SOLTER, D. (1984). Inability of mouse blastomore nuclei transferred to enucleated zygotes to support development in vitro. Science, 266: 1317-1319.MARX, J.L. (1984). Genes the control development. Science, 213: 1485-88.MERCIER, J.C. (1986). Genetic engineering applied to milk producing animals: some expectations. In: Exploiting news tecnologies breeding. Genetic Development, 202 pp.NICHOLAS, F.W.C. (1983). Increased rates of genetic change in dairy cattle by embryo transfer and splitting. Ann. Prod., 36: 341-353.NICHOLAS, F.W. (1987). Recombinant DNA. In: Veterinary Genetics, 580 pp. NORDSKOG, A.W. (1983). Immunogenetics as an aid to selection for disease resistance in the fowl. World's Poultry Science Journal, 39: 199-209.NOBEM, L. LECTURES. The 1980 Nobel Prize in Physiology or Medicine was awarded to Bary Benacerraf, George Snell and Jean Dausset for their pioneering work on the MHC of various species. Science, 212: 1229-38, Science, 213: 172-8 and Science, 213: 1469-74.OZIL, J.P.; HEYMAN, Y.; RENARD, J.P. (1982). Production of monozigotic twins by micromanipulation and cervical transfer in the cow. Vet. Rec., 110: 126.PUCK, T. & KAO, F.T. (1982). Somatic cell genetics and its application to medicine. Ann. Rev. Genet., 16: 225-72.REXROAD, C.E. (1985). History of Genetic Engineering of Laboratory and Farm Animals. In: Genetic Engineering of Animals, 315 pp.REED, P.D. & VAN VLECK, L.D. (1987). Lack of evidence of citoplasmic inheritance in milk production traits of dairy cattle. J. Dairy Sci., 70: 837-838.ROBINS, D.M.; RIPLEY, S.; HENDERSON, A.S.; AXEL, R. (1981). Transferring DNA integrates into the host chromossome. Cell, 23: 29-39.SHANI, M. (1985). Tissue-specific expression of rat miosin light-chain 2 gene in transfenic mice. Nature, 314: 283-6.SPOONER, R.L.(1985). The bovine MHC. BOLA Newsletter, 1:3-9.SINGER, P.S. (1985). Expression of a microinjected procine class I major histocompatibility complex in transgenic mice. Science, 228: 577-580.SMITH, C. (1986). Use of embryo transfer in genetic improvement of sheep. Anim. Prod., 42: 81-88.SEIDEL, G.E. (1985). Characteristics of future agricultural animals. In: Genetic Engineering of animals, 315 pp.SCOTT, A.M. & JEFFCOTT, L.B. (1978). Haeemolytic disease of the newborn foal. Veterinary Record, 103: 71-4.STEAR, M.J. (1982). The future role of immunogenetics in animal breeding, University Canberra, Australia.TOELLE, V.D.; Mc DANIEL, B.T.; ROBINSON, O.N. (1986). Cytoplasmic effects in swine. J. Anim. Sci., 63: (Suppl.1): 203.WIENER, F.; SPIRA, J.; BANERJEE, M.; KLEING, G. (1985). Somatic Cell. Mol. Genet., 493: 498.WAGNER, E.F.L.; COVARRUBIAS, T.A.; STEWART, J.C.; MINITZ, B. (1984). Prenatal lethalities in mice homozigous of grouth hormone gene sequences integrated into the germ line. Cell, 35: 647-655.WHITE, R. (1985). DNA sequence polimorphisms revitalize linkage approaches in human genetics. Trends in Genet., 1: 177-80.
 

Clique para consultar os requisitos para VNP0241

Clique para consultar o oferecimento para VNP0241

Créditos | Fale conosco
© 1999 - 2024 - Superintendência de Tecnologia da Informação/USP